Clinical trial for Infertility, Female
Official title SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
ClinicalTrials.gov ID: NCT07175571
What this study is testing
- What it's testing
- The study wants to find out if intracytoplasmic sperm injection (ICSI) or conventional in‑vitro fertilization (IVF) produces more usable embryos, better embryo quality, or higher early pregnancy rates when using frozen donor sperm.
- Who it's for
- It is looking for people who have infertility that is not caused by male problems and who are using frozen donor sperm.
- What's involved
- Participants will have their eggs split into two groups. One group will be fertilized by ICSI, where a single sperm is injected into each egg, and the other group will be fertilized by conventional IVF, where eggs and sperm are mixed together. The assignment of eggs to each method is random. The rest of the fertility treatment continues as usual while the study compares the results.
- Time commitment
- The study lasts as long as the normal fertility treatment cycle, with visits for egg retrieval, fertilization, and embryo monitoring.
- Time commitment: about 12 months
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Adults, women only
You may be able to join if
- Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center
- Normal ovarian reserve (AMH \> 1 ng/mL, AFC \> 10)
- Absence of male factor infertility
- Post-wash parameters: \>50% motility, \>5mil concentration
- \> 4 oocytes retrieved at time of transvaginal oocyte retrieval
You likely can't join if
- Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology)
- Any medical condition contraindicating ART
The study team makes the final eligibility decision.
Where it is enrolling
- Rockville, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 12 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling female, not specified. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Rockville, Maryland, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.