Clinical trial for Amyotrophic Lateral Sclerosis (ALS)
Official title Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
ClinicalTrials.gov ID: NCT07187388
What this study is testing
- What it's testing
- The study wants to see whether non‑invasive electrical stimulation on facial muscles reduces facial pain, improves jaw mobility, and helps chewing. It also looks at whether the treatment makes it easier to clean teeth and gums.
- Who it's for
- Adults who have amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS).
- What's involved
- Participants will come to a clinic for one visit where they will receive a single 30‑minute electrical stimulation session while seated. Before and after the session, they will rate their jaw and facial pain, test how wide and far they can open their mouth, and chew a cracker. Twenty‑four hours later, they will get a phone call to rate pain again and report any trouble with oral hygiene.
- Time commitment
- The study lasts about one day: a clinic visit and a 24‑hour follow‑up phone call.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Diagnosis of possible, probable, or definite ALS (El-Escorial Revisited) OR diagnosis of definite PLS by the treating neurologist and based on the...
- Subjective report of jaw pain, indicated by a NRS score of \> or = 3/10.
You likely can't join if
- history of head or neck cancer
- history of CVA
- history of past facial surgery with hardware placement
- history of pacemaker
- diagnosis of significant cognitive impairment by the treating physician
- history of seizures or diagnosis of epilepsy
See the full eligibility criteria
- Diagnosis of possible, probable, or definite ALS (El-Escorial Revisited) OR diagnosis of definite PLS by the treating neurologist and based on the consensus diagnostic criteria for PLS
- Subjective report of jaw pain, indicated by a NRS score of \> or = 3/10.
- history of head or neck cancer
- history of CVA
- history of past facial surgery with hardware placement
- history of pacemaker
- diagnosis of significant cognitive impairment by the treating physician
- history of seizures or diagnosis of epilepsy
- open wound at the area of electrode placement
- complete loss of sensation at the area of electrode placement
The study team makes the final eligibility decision.
Where it is enrolling
- Davie, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Davie, Florida, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.