Glioblastoma study: GammaTile® vs Temozolomide
Official title Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care
ClinicalTrials.gov ID: NCT07195591
What this study is testing
What is Temozolomide?
an investigational chemotherapy drug being studied as a potential treatment for glioblastoma is designed to damage the DNA of cancer cells, which can stop them from growing and cause them to die
Also referred to as TMZ.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether adding a small radiation device to surgery works better than standard care. It looks at how well this new setup helps people with glioblastoma.
- Who it's for
- You may be able to join if you have glioblastoma and are ready for surgery.
- What's involved
- You would have surgery to remove the tumor. Some people also get a small radiation device placed in the brain. You would then get standard radiation and pill treatments.
- Time commitment
- The study lasts about six months with regular check-ins and scans.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients must be ≥18 years of age.
- Have radiographic suspicion of newly diagnosed glioblastoma (GBM). o If final pathology reports IDH mutant glioma, then the patients found to have an...
- Are medically and surgically appropriate for resection.
- Have an estimated Karnofsky Performance Scale (KPS) score of ≥70.
- Are able to receive standard of care treatment.
You likely can't join if
- A previous biopsy diagnosis other than IDH wild-type GBM.
- Have contraindications to TMZ, magnetic resonance imaging, gadolinium, or non-contrast computed tomography.
- Have multi-focal enhancing tumors that cannot be encompassed in one operative field.
The study team makes the final eligibility decision.
Where it is enrolling
- Scottsdale, Arizona, United States
- Los Angeles, California, United States
- San Francisco, California, United States
- Littleton, Colorado, United States
- Orlando, Florida, United States
- Atlanta, Georgia, United States
- Chicago, Illinois, United States
- Louisville, Kentucky, United States
- Baltimore, Maryland, United States
- Columbia, Missouri, United States
- Lebanon, New Hampshire, United States
- Neptune City, New Jersey, United States
- Valhalla, New York, United States
- Greenville, North Carolina, United States
- Columbus, Ohio, United States
- Pittsburgh, Pennsylvania, United States
- Providence, Rhode Island, United States
- Charleston, South Carolina, United States
- Houston, Texas, United States
- Fairfax, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Scottsdale, Arizona, United States; Los Angeles, California, United States; San Francisco, California, United States; Littleton, Colorado, United States; Orlando, Florida, United States; Atlanta, Georgia, United States and 14 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.