Urinary Incontinence,Stress study: Orforglipron
Official title A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
ClinicalTrials.gov ID: NCT07202884
What this study is testing
What is Orforglipron?
Orforglipron is an investigational medicine, taken by mouth, being studied as a potential treatment for urinary incontinence,stress.
Also referred to as LY3502970.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if the drug orforglipron is safe and effective for treating stress urinary incontinence.
- Who it's for
- The study is looking for adult women who have obesity or are overweight and leak urine when coughing or exercising.
- What's involved
- Participants will take orforglipron and undergo medical tests to check how well it works and if it causes any side effects.
- Time commitment
- The study lasts about 58 weeks, including initial screening and final safety follow-up visits.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, women only
You may be able to join if
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have a diagnosis of stress urinary incontinence
You likely can't join if
- Have had urinary incontinence surgery
- Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
- Have given birth within one year of screening
- Have had a change in body weight of more than 11 pounds within 90 days prior to screening
- Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
See the full eligibility criteria
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have a diagnosis of stress urinary incontinence
- Have had urinary incontinence surgery
- Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
- Have given birth within one year of screening
- Have had a change in body weight of more than 11 pounds within 90 days prior to screening
- Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have had a cardiovascular health condition within 90 days prior to screening
- Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed for the duration of the study
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Mobile, Alabama, United States
- Los Angeles, California, United States
- Montebello, California, United States
- Lakewood, Colorado, United States
- Fort Myers, Florida, United States
- Lake Worth, Florida, United States
- Miami, Florida, United States
- Panama City, Florida, United States
- Lawrenceville, Georgia, United States
- Troy, Michigan, United States
- Erie, Pennsylvania, United States
- Houston, Texas, United States
- Newport News, Virginia, United States
- Virginia Beach, Virginia, United States
- Bellevue, Washington, United States
- Seattle, Washington, United States
- Kelowna, Canada
- Lévis, Canada
- Oakville, Canada
+ 63 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Mobile, Alabama, United States; Los Angeles, California, United States; Montebello, California, United States; Lakewood, Colorado, United States; Fort Myers, Florida, United States and 77 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.