Symptomatic Venous Thromboembolism study: REGN7508 vs Acetylsalicylic Acid
Official title REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
ClinicalTrials.gov ID: NCT07213778
What this study is testing
What is REGN7508?
REGN7508 is an investigational drug being studied to prevent symptomatic venous thromboembolism (VTE) after total knee replacement surgery.
Also referred to as cenvacibart.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to know if REGN7508 works better than aspirin at stopping blood clots after knee replacement, and to check its safety, how it moves in the body, and whether the body makes antibodies against it.
- Who it's for
- Adults who are having an elective, one‑side total knee replacement.
- What's involved
- Participants will be given either REGN7508 or aspirin after surgery, have blood draws to measure drug levels and antibodies, and be monitored for side effects.
- Time commitment
- Participants are followed for several weeks after the operation with clinic visits and blood tests.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Is undergoing a primary elective unilateral TKA
- Is in good health based on laboratory safety testing as described in the protocol Key
You likely can't join if
- Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study...
- History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion
- History of thromboembolic disease or thrombophilia
- History of platelet dysfunction
- Has received or plans to receive preoperative enoxaparin on the day prior to TKA surgery Note: Other protocol-defined Inclusion/ Exclusion criteria...
The study team makes the final eligibility decision.
Where it is enrolling
- La Mesa, California, United States
- Rancho Mirage, California, United States
- Riverside, California, United States
- Englewood, Colorado, United States
- Lone Tree, Colorado, United States
- Deerfield Beach, Florida, United States
- Delray Beach, Florida, United States
- Miami, Florida, United States
- South Miami, Florida, United States
- Tamarac, Florida, United States
- Skokie, Illinois, United States
- Indianapolis, Indiana, United States
- Wichita, Kansas, United States
- Annapolis, Maryland, United States
- Baltimore, Maryland, United States
- Boston, Massachusetts, United States
- Teaneck, New Jersey, United States
- New York, New York, United States
- Rochester, New York, United States
- Williamsville, New York, United States
+ 30 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at La Mesa, California, United States; Rancho Mirage, California, United States; Riverside, California, United States; Englewood, Colorado, United States; Lone Tree, Colorado, United States; Deerfield Beach, Florida, United States and 44 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.