Atopic Dermatitis study: PF-08049820
Official title A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema
ClinicalTrials.gov ID: NCT07216027
What this study is testing
What is PF-08049820?
PF-08049820 is an investigational oral tablet being studied for the treatment of atopic dermatitis (eczema).
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see if PF‑08049820 is safe and works for treating eczema. It compares the medicine to a placebo.
- Who it's for
- Adults aged 18‑64 with moderate to severe eczema that has lasted at least six months and who have no suitable prescribed treatment.
- What's involved
- Participants take either the study medicine or a placebo tablet every day for 12 weeks. They visit the clinic on Day 1, Weeks 1, 2, 4, 6, 8, 12 and a follow‑up at Week 16. At visits, doctors check health and skin, do blood and urine tests, and ask about symptoms and daily impact.
- Time commitment
- The study lasts 16 weeks, with daily medication for 12 weeks and clinic visits at the times listed above.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 64
You may be able to join if
- Are 18 to 64 years of age
- Have clinical diagnosis of AD for at least 6 months prior to Day 1 and have diagnosis of AD confirmed by photographs
- Affected body surface area (BSA) greater than or equal to 10% and up to 60%;
- Validated Investigator's Global Assessment (vIGA) greater than or equal to 3;
- Eczema Area and Severity Index (EASI) greater than or equal to 16; AND -Peak Pruritis Numeric Rating Scale (PP-NRS) greater than or equal to 4 at...
You likely can't join if
- Have an infection that requires treatment
- Have other skin conditions other than AD
- Have severe uncontrolled asthma
- Regular use (more than 2 visits per week) of a tanning booth or phototherapy for AD within 4 weeks of the screening visit
See the full eligibility criteria
- Are 18 to 64 years of age
- Have clinical diagnosis of AD for at least 6 months prior to Day 1 and have diagnosis of AD confirmed by photographs
- Affected body surface area (BSA) greater than or equal to 10% and up to 60%;
- Validated Investigator's Global Assessment (vIGA) greater than or equal to 3;
- Eczema Area and Severity Index (EASI) greater than or equal to 16; AND -Peak Pruritis Numeric Rating Scale (PP-NRS) greater than or equal to 4 at screening and a weekly average of greater than or equal to 4 at baseline...
- Do not have a suitable prescribed medicine for AD.
- Body Mass Index (BMI) of 18 to 38 kg/m2 and a total body weight greater than 48 kg (106 lbs)
- Have an infection that requires treatment
- Have other skin conditions other than AD
- Have severe uncontrolled asthma
- Regular use (more than 2 visits per week) of a tanning booth or phototherapy for AD within 4 weeks of the screening visit
The study team makes the final eligibility decision.
Where it is enrolling
- Phoenix, Arizona, United States
- Scottsdale, Arizona, United States
- Huntington Beach, California, United States
- Northridge, California, United States
- Santa Monica, California, United States
- Margate, Florida, United States
- The Bronx, New York, United States
- Lorain, Ohio, United States
- Mayfield Heights, Ohio, United States
- Philadelphia, Pennsylvania, United States
- Pittsburgh, Pennsylvania, United States
- Calgary, Alberta, Canada
- Toronto, Ontario, Canada
- Québec, Canada
- Fuzhou, Fujian, China
- Guangzhou, Guangdong, China
- Shanghai, Shanghai Municipality, China
- Beijing, China
- Náchod, Czechia
- Ostrava, Czechia
+ 14 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Phoenix, Arizona, United States; Scottsdale, Arizona, United States; Huntington Beach, California, United States; Northridge, California, United States; Santa Monica, California, United States; Margate, Florida, United States and 28 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.