Post Operative Pain study: Methadone
Official title Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
ClinicalTrials.gov ID: NCT07222072
What this study is testing
What is Methadone?
An investigational oral medication being studied for postoperative pain after spine surgery.
Also referred to as Methadone.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study will see if giving methadone after spine surgery is safe and doable, and will gather early data to plan a larger trial that looks at opioid use 3 months later.
- Who it's for
- Adults who have just had major spine surgery and are expected to need pain medication afterward.
- What's involved
- Participants will receive either methadone or a placebo after surgery, and will be monitored by doctors and researchers who do not know which treatment they got. They will have regular visits and tests to check safety and pain control.
- Time commitment
- The study lasts a few weeks after surgery, with several follow‑up visits to monitor safety and pain levels.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 72. Healthy volunteers may be eligible.
You may be able to join if
- Adult ≥ 18 years of age
- Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision)
You likely can't join if
- \ 72 Years of age
- Body Mass Index \>40
- Known allergy to methadone
- Pregnant females
- Non-English-speaking patients
The study team makes the final eligibility decision.
Where it is enrolling
- Cleveland, Ohio, United States
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 72 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Cleveland, Ohio, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.