Asthma study: Dexamethasone vs Prednisone
Official title Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
ClinicalTrials.gov ID: NCT07228052
What this study is testing
What is Dexamethasone 16mg IM?
Dexamethasone 16mg IM is an investigational medicine, given as an injection into a muscle, being studied as a potential treatment for asthma.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether one shot of dexamethasone works as well as five days of prednisone pills. It looks at how well each option helps prevent a return to the emergency room.
- Who it's for
- You may be able to join if you are an adult with asthma who is in the emergency room.
- What's involved
- You would get either one steroid shot or five days of steroid pills. You would be picked by chance, like a coin toss, to get one or the other.
- Time commitment
- The study involves a short visit to the emergency room and later check-ins to see if you return.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults ≥18 years old presenting to the ED with an asthma exacerbation
- Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
- Discharged from the ED with a primary diagnosis of asthma exacerbation
- Initiated systemic corticosteroids during the ED visit
- Must be English or Spanish speaking
You likely can't join if
- Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
- History of severe adverse reactions to corticosteroids
- Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
- Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
- Inability to provide informed consent
The study team makes the final eligibility decision.
Where it is enrolling
- The Bronx, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at The Bronx, New York, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.