Diabetic Peripheral Neuropathic Pain study: Suzetrigine
Official title Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov ID: NCT07231419
What this study is testing
What is Suzetrigine?
Suzetrigine is an investigational oral tablet being studied as a potential treatment for diabetic peripheral neuropathic pain.
Also referred to as VX-548, SUZ.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out whether Suzetrigine works, is safe, and is tolerated by people with diabetic nerve pain.
- Who it's for
- Adults who have pain caused by diabetic peripheral neuropathy.
- What's involved
- Participants will be given Suzetrigine or a placebo and will have regular clinic visits and safety tests.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Body weight greater than or equal to (≥)45 kilogram (kg)
- Body mass index (BMI) ≥18 to less than (\<) 40 kilogram per meter square (kg/m\^2)
- Diagnosis of diabetes mellitus type 1 or type 2 and with glycosylated hemoglobin A1c (HbA1c) ≤9% and the presence of bilateral pain in lower...
- Weekly average of daily NPRS score ≥4 and less than or equal to (≤) 9 with limited variation in the 7-day Baseline Period Key
You likely can't join if
- More than 3 missing daily NPRS scores during the 7-day Baseline Period
- Received Journavx within 30 days of study drug dosing
- Any sensory abnormality (excluding DPN) as pre-specified in the protocol Other protocol defined Inclusion/Exclusion criteria may apply.
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Glendale, Arizona, United States
- Scottsdale, Arizona, United States
- Little Rock, Arkansas, United States
- Canoga Park, California, United States
- Huntington Beach, California, United States
- La Mesa, California, United States
- Long Beach, California, United States
- Modesto, California, United States
- Pasadena, California, United States
- Riverside, California, United States
- San Bernardino, California, United States
- Boulder, Colorado, United States
- Wheat Ridge, Colorado, United States
- Waterbury, Connecticut, United States
- Washington D.C., District of Columbia, United States
- Boca Raton, Florida, United States
- DeLand, Florida, United States
- Hallandale, Florida, United States
- Jacksonville, Florida, United States
+ 49 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Glendale, Arizona, United States; Scottsdale, Arizona, United States; Little Rock, Arkansas, United States; Canoga Park, California, United States; Huntington Beach, California, United States and 63 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.