Stroke study: Minocycline
Official title Minocycline in Stroke Study at Maimonides
ClinicalTrials.gov ID: NCT07237048
What this study is testing
What is Minocycline 200mg?
This is an investigational antibiotic medicine being studied to see if it helps people recover from a stroke. It is designed to reduce inflammation and protect brain cells from damage.
Also referred to as Minocin, Minocycline hydrochloride.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to see if minocycline improves brain‑function scores and reduces disability and death after a stroke.
- Who it's for
- Adults 18 or older who have had a moderate stroke, either blocked or bleeding in the brain.
- What's involved
- Participants will take minocycline 200 mg by mouth once a day for five days, or no minocycline, while receiving standard stroke care. They will have brain‑function tests at admission, discharge, 30 days, and 90 days, and doctors will watch for bleeding, side effects, and death.
- Time commitment
- The study lasts about three months, with visits at the hospital and follow‑up calls or visits at 30 and 90 days after the stroke.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age \>/=18
- NIHSS 5-20 \ National Institutes of Health Stroke Scale\
- Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO \ (World Health...
- The onset of neurological symptoms less than 24 hours
You likely can't join if
- Clinically stroke is not suspected
- Allergic to the Tetracycline group of medications or Intolerance to Minocycline
- Pregnancy or suspected pregnancy or breastfeeding
- Previous history of intolerance to Minocycline
- Acute or chronic renal failure (stage III with GFR \ (Glomerular Filtration Rate) \ or Creatinine threshold)
- Any patients with contraindications to undergo CT (Computed Tomography) / MRI (Magnetic Resonance Imaging)
See the full eligibility criteria
- Age \>/=18
- NIHSS 5-20 \ National Institutes of Health Stroke Scale\
- Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO \ (World Health Organization) \ guidelines or acute onset of neurological deficits...
- The onset of neurological symptoms less than 24 hours
- Clinically stroke is not suspected
- Allergic to the Tetracycline group of medications or Intolerance to Minocycline
- Pregnancy or suspected pregnancy or breastfeeding
- Previous history of intolerance to Minocycline
- Acute or chronic renal failure (stage III with GFR \ (Glomerular Filtration Rate) \ or Creatinine threshold)
- Any patients with contraindications to undergo CT (Computed Tomography) / MRI (Magnetic Resonance Imaging)
- Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
- Pre-existing infectious disease requiring antibiotics
- Inability to tolerate enteral medications/feeds
- Patient/ family refusal
The study team makes the final eligibility decision.
Where it is enrolling
- Brooklyn, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Brooklyn, New York, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.