Depression - Major Depressive Disorder study: Psychotherapy
Official title Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
ClinicalTrials.gov ID: NCT07250893
What this study is testing
- What it's testing
- The study wants to find out if the therapy improves mood and reduces distress, and whether it changes biological markers linked to early stress.
- Who it's for
- Adults who have major depressive disorder and a history of childhood trauma.
- What's involved
- Participants will attend therapy sessions, answer health questionnaires, and give blood samples for lab analysis.
- Time commitment: about 3 months
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65, women only
You may be able to join if
- Adults 18 years old or older
- At or above 18 on HAM-D, indicative of moderate-severe depressive symptoms
- Any childhood (before 18 years old) adversity as indicated by scores on the CECA q and ACES q
You likely can't join if
- Individuals who meet for PTSD diagnosis from a criterion A trauma occurring in adulthood without a history of ELA
- Individuals experiencing active mania or psychosis
- Individuals with an active substance use disorder
- Individuals presenting with active suicide risk (plan, intention, means) indicative of a need for higher level care
- Individuals in current psychotherapeutic treatment (defined as having engaged in consistent psychotherapy within the last 3 months)
The study team makes the final eligibility decision.
Where it is enrolling
- Hamilton, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The study runs about 3 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling female, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Hamilton, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.