PCOS study: Letrozole vs Cabergoline
Official title Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS
ClinicalTrials.gov ID: NCT07255911
What this study is testing
What is Letrozole 0.5mg?
Letrozole 0.5mg is an investigational medicine, taken by mouth once daily, being studied as a potential treatment for pcos.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out whether the combination of cabergoline and letrozole improves ovulation rates compared with letrozole alone in women with polycystic ovary syndrome (PCOS).
- Who it's for
- Women diagnosed with PCOS who are trying to induce ovulation.
- What's involved
- Participants will take either cabergoline plus letrozole or letrozole alone and will have ultrasound monitoring of their ovaries for three cycles.
- Time commitment
- The study lasts for three menstrual cycles with regular ultrasound visits to check ovarian response.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, women only
You may be able to join if
- PCOS patients diagnosed according to Rotterdam criteria.
- Age: 18-35 years.
- Primary or secondary subfertility.
- Selected for ovulation induction.
You likely can't join if
- Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome.
- Serum prolactin (more than 50 ng/ml) (Kyritsi et al., 2018).
- Male factor infertility.
- Women with other infertility factors (endometriosis, PID,uterine \& tubal causes of infertility).
- Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease).
- History of hypersensitivity to cabergoline \& letrozole.
See the full eligibility criteria
- PCOS patients diagnosed according to Rotterdam criteria.
- Age: 18-35 years.
- Primary or secondary subfertility.
- Selected for ovulation induction.
- Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome.
- Serum prolactin (more than 50 ng/ml) (Kyritsi et al., 2018).
- Male factor infertility.
- Women with other infertility factors (endometriosis, PID,uterine \& tubal causes of infertility).
- Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease).
- History of hypersensitivity to cabergoline \& letrozole.
- Thyroid dysfunction ( serum TSH ≥5mIU/L)
- BMI:\< 18.5 kg/m2 and ≥30 kg/m2.
- Patients on metformin therapy.
- Patient on antiemetic like Domperidone metoclopramide, antipsychotic drug like haloperidol and risperidone, tricyclic antidepressant like amitriptyline, clomipramine, antihypertensive like verapamil, methyldopa...
The study team makes the final eligibility decision.
Where it is enrolling
- Dhaka, Shahbag, Bangladesh
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 35 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Dhaka, Shahbag, Bangladesh. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.