Diabetic Kidney Disease study: ALN-ANG3 vs Evinacumab
Official title Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
ClinicalTrials.gov ID: NCT07271186
What this study is testing
What is ALN-ANG3?
This is an investigational medicine being studied to see if it can help treat diabetic kidney disease.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if the new drug is safe and effective. It also looks at side effects and how much of the drug stays in the blood.
- Who it's for
- Adults who have diabetic kidney disease.
- What's involved
- Participants will take the study drug and have regular tests to check their health and blood levels.
- Time commitment
- The source text does not specify the total duration or number of visits.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management
- Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening
- eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and...
- Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening Key
You likely can't join if
- Known medical history or clinical evidence indicative of non-diabetic renal disease
- Renal disease that required treatment with systemic immunosuppressive therapy (prior or current), or a history of end-stage kidney disease requiring...
- Medically unstable as assessed by the investigator or hospitalization (ie, \>24 hours) within 30 days of the screening visit NOTE: Other...
The study team makes the final eligibility decision.
Where it is enrolling
- Huntsville, Alabama, United States
- Little Rock, Arkansas, United States
- Huntington Beach, California, United States
- Northridge, California, United States
- Oxnard, California, United States
- San Dimas, California, United States
- Santa Clarita, California, United States
- Tarzana, California, United States
- Valencia, California, United States
- Victorville, California, United States
- New Haven, Connecticut, United States
- Doral, Florida, United States
- Hialeah, Florida, United States
- Hollywood, Florida, United States
- Margate, Florida, United States
- Miami, Florida, United States
- Miami Springs, Florida, United States
- Miramar, Florida, United States
- Orlando, Florida, United States
- Pembroke Pines, Florida, United States
+ 29 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Huntsville, Alabama, United States; Little Rock, Arkansas, United States; Huntington Beach, California, United States; Northridge, California, United States; Oxnard, California, United States; San Dimas, California, United States and 43 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.