Clinical trial for Alzheimer Disease
Official title Deep Cervical LymphatIc-Venous Anastomosis for Alzheimer's Disease
ClinicalTrials.gov ID: NCT07294885
What this study is testing
- What it's testing
- Lymphaticovenous anastomosis (LVA) is a microsurgical technique that involves anastomosing fine lymphatic vessels with adjacent veins to reestablish lymphatic drainage pathways.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80
You may be able to join if
- Age 50-80 years (inclusive), regardless of gender.
- Meeting the diagnostic criteria for Mild Cognitive Impairment or mild to moderate dementia due to Alzheimer's disease (according to the 2024 AA...
- Disease duration of 6 months or longer, with no clinical improvement after 3 months or more of conservative treatment.
- MMSE score: 12-26.
- Biomarker confirmation of AD: positive Aβ-PET and tau-PET, or positive cerebrospinal fluid biomarkers.
You likely can't join if
- Contraindications to MRI, ICG angiography, or PET.
- Contraindications to surgery or anesthesia, such as coagulation disorders (platelet count \ 1.7).
- Comorbid major organ dysfunction, such as reduced left ventricular ejection fraction, severe hepatic or renal insufficiency (AST or ALT \>3 times the...
- Intracranial structural lesions indicated by MRI, including brain tumors, cerebral infarction, intracranial hemorrhage, aneurysms, arteriovenous...
- MRI findings suggestive of significant cerebral small vessel disease features: more than one lacunar infarction in the deep white matter and...
- Other causes of dementia, such as hypothyroidism or vitamin B12 deficiency.
See the full eligibility criteria
- Age 50-80 years (inclusive), regardless of gender.
- Meeting the diagnostic criteria for Mild Cognitive Impairment or mild to moderate dementia due to Alzheimer's disease (according to the 2024 AA clinical diagnostic criteria for AD-related dementia).
- Disease duration of 6 months or longer, with no clinical improvement after 3 months or more of conservative treatment.
- MMSE score: 12-26.
- Biomarker confirmation of AD: positive Aβ-PET and tau-PET, or positive cerebrospinal fluid biomarkers.
- Having a reliable caregiver (providing companionship for ≥3 hours per day).
- Signed written informed consent from the patient or legally authorized representative.
- Contraindications to MRI, ICG angiography, or PET.
- Contraindications to surgery or anesthesia, such as coagulation disorders (platelet count \ 1.7).
- Comorbid major organ dysfunction, such as reduced left ventricular ejection fraction, severe hepatic or renal insufficiency (AST or ALT \>3 times the upper limit of normal; eGFR \<30 mL/min/1.73m²).
- Intracranial structural lesions indicated by MRI, including brain tumors, cerebral infarction, intracranial hemorrhage, aneurysms, arteriovenous malformations, hydrocephalus, etc.
- MRI findings suggestive of significant cerebral small vessel disease features: more than one lacunar infarction in the deep white matter and periventricular regions and/or white matter hyperintensity (WMH) with a...
- Other causes of dementia, such as hypothyroidism or vitamin B12 deficiency.
- Drug/alcohol addiction.
- Severe psychiatric illness or suicide risk.
- Comorbid medical conditions with a life expectancy of less than 1 year.
- Participation in another treatment trial within the past 3 months.
- Poor compliance or judged by the investigator as unsuitable for participation.
- Patients receiving therapy with Lecanemab or Donanemab.
- Other conditions that the researcher deems unsuitable for participation in this study.
The study team makes the final eligibility decision.
Where it is enrolling
- Shenyang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Shenyang, China. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.