Healthy Participants study: Fluzone® High-Dose vs MK-1406 Injection
Official title A Trial to Evaluate the Effect of CD388/MK1406 on the Immunogenicity of Fluzone® HD Vaccine (CD388.SQ.1.08/MK-1406-007)
ClinicalTrials.gov ID: NCT07300085
What this study is testing
What is Fluzone® High-Dose (HD) influenza vaccine?
Fluzone® High-Dose (HD) influenza vaccine is an investigational medicine, given as an injection into a muscle, being studied as a potential treatment for healthy participants.
Also referred to as Fluzone® High-Dose Influenza Vaccine.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Approximately one billion cases of seasonal influenza occur annually. Of these, 3 to 5 million illnesses are severe and responsible for up to 650,000 deaths per year (WHO 2025).
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 49. Healthy volunteers may be eligible.
You may be able to join if
- Be ≥18 to ≤49 years of age
- Be deemed healthy by the Investigator
- Have not received any seasonal influenza vaccine and have not had a diagnosed or suspected influenza infection within 12 months prior to Day 1 of the...
You likely can't join if
- Had an active malignancy within 5 years prior to screening, except basal cell or squamous cell skin cancer.
- Has previously been diagnosed with Guillain-Barre Syndrome following a previous influenza vaccination.
The study team makes the final eligibility decision.
Where it is enrolling
- Glendale, California, United States
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 49 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Glendale, California, United States; Baltimore, Maryland, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.