Osteoarthritis study: Eloralintide
Official title Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
ClinicalTrials.gov ID: NCT07353931
What this study is testing
What is Eloralintide?
This is an investigational injectable medicine being studied to see if it can help with knee pain in people with osteoarthritis.
Also referred to as LY3841136.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if the drug Eloralintide is safe and effective for treating knee pain caused by osteoarthritis.
- Who it's for
- The study is looking for adults who have knee pain from osteoarthritis and are overweight or have obesity.
- What's involved
- Participants will receive the study drug and undergo medical tests to monitor their health and pain levels.
- Time commitment
- The study lasts about 75 weeks, including the initial screening period.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
- Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
You likely can't join if
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before...
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was...
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have an active knee infection
- heart attack
- stroke
See the full eligibility criteria
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
- Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
- Have a crackling or grinding sound or feeling in the knee
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have an active knee infection
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
- Have taken medications or alternative remedies intended for weight loss within 90 days of screening
The study team makes the final eligibility decision.
Where it is enrolling
- Mobile, Alabama, United States
- Mesa, Arizona, United States
- Phoenix, Arizona, United States
- Tucson, Arizona, United States
- Fountain Valley, California, United States
- Santa Ana, California, United States
- Spring Valley, California, United States
- Walnut Creek, California, United States
- Colorado Springs, Colorado, United States
- Jacksonville, Florida, United States
- St. Petersburg, Florida, United States
- Winter Park, Florida, United States
- Decatur, Georgia, United States
- Woodstock, Georgia, United States
- Ammon, Idaho, United States
- Chicago, Illinois, United States
- Evansville, Indiana, United States
- Newton, Kansas, United States
- Louisville, Kentucky, United States
- Burlington, Massachusetts, United States
+ 93 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Mobile, Alabama, United States; Mesa, Arizona, United States; Phoenix, Arizona, United States; Tucson, Arizona, United States; Fountain Valley, California, United States; Santa Ana, California, United States and 107 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.