Parkinson's Disease study: Exercise
Official title Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
ClinicalTrials.gov ID: NCT07442747
What this study is testing
- What it's testing
- The study wants to learn how aerobic exercise changes movement, thinking and brain activity in these patients.
- Who it's for
- People with Parkinson's disease who already have a deep‑brain‑stimulation device.
- What's involved
- Participants will ride a stationary bike, either with the bike controlling the pace (forced) or at their own speed (voluntary), and will have visits for movement tests, thinking tests, and brain scans.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Clinical diagnosis of Parkinson's disease
- Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD
- Clinically optimized DBS parameters for one month prior to enrollment
- Ability to ambulate with or without an assistive device for 5 continuous minutes
- Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments
You likely can't join if
- Neurocognitive impairment that compromises the ability to provide informed consent
- Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)
- A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise
- Current cardiac arrhythmia
See the full eligibility criteria
- Clinical diagnosis of Parkinson's disease
- Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD
- Clinically optimized DBS parameters for one month prior to enrollment
- Ability to ambulate with or without an assistive device for 5 continuous minutes
- Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments
- Medical clearance for moderate-high intensity exercise given by treating physician or physician extender
- Neurocognitive impairment that compromises the ability to provide informed consent
- Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)
- A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise
- Current cardiac arrhythmia
The study team makes the final eligibility decision.
Where it is enrolling
- Cleveland, Ohio, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Cleveland, Ohio, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.