Clinical trial for Overweight/Obesity
Official title Effects of Cranberry on Gut and Metabolic Health
ClinicalTrials.gov ID: NCT07460856
What this study is testing
- What it's testing
- The study wants to see whether cranberry supplementation changes glucose control, insulin sensitivity, blood lipids, and gut microbiome in people who are overweight or obese.
- Who it's for
- Adults who are overweight or obese and have signs of metabolic syndrome or insulin resistance.
- What's involved
- Participants will drink a cranberry beverage for 12 weeks, then a placebo for 12 weeks (or vice‑versa) with a 4‑week washout in between, after a 2‑week stable diet period. They will have blood tests, body composition checks, gut‑microbe analysis, and some will get a liver MRI.
- Time commitment
- The trial lasts about 30 weeks total, with visits at the start, after each 12‑week period, and for follow‑up testing.
You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 70. Healthy volunteers may be eligible.
You may be able to join if
- body mass index between 25 and 40 kg/m2
- at least one of the following criteria: fasting plasma insulin \>60 pmol/L, fasting glycemia between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c)...
You likely can't join if
- to have aversion to cranberry products
- regularly drinking alcohol (\>2 glasses/day)
- having a significant change in body weight in the past 3 months (±5% of their body weight) due to bariatric surgery or other conditions
- taking medication which may affect the study outcomes (i.e. antidiabetic and/or cholesterol or lipid-lowering medications and/or glucocorticosteroid...
- taking regular probiotics and prebiotics (including fruit/berry polyphenol supplements) in the past 3 months
- having eating disorders
See the full eligibility criteria
- body mass index between 25 and 40 kg/m2
- at least one of the following criteria: fasting plasma insulin \>60 pmol/L, fasting glycemia between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c) level of 5.7- 6.4% and/or fasting triglyceride \>1.35 mmol/L.
- to have aversion to cranberry products
- regularly drinking alcohol (\>2 glasses/day)
- having a significant change in body weight in the past 3 months (±5% of their body weight) due to bariatric surgery or other conditions
- taking medication which may affect the study outcomes (i.e. antidiabetic and/or cholesterol or lipid-lowering medications and/or glucocorticosteroid in supraphysiological doses and/or anti-obesity medications)
- taking regular probiotics and prebiotics (including fruit/berry polyphenol supplements) in the past 3 months
- having eating disorders
- had undergone major surgery 3 months prior to the study or if they had one planned
- if they had intestinal malabsorption, cirrhosis or chronic kidney disease
- being pregnant, planning a pregnancy, or breastfeeding.
The study team makes the final eligibility decision.
Where it is enrolling
- Québec, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Québec, Quebec, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.