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New treatment option for Hypertension, Pulmonary
Official title Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
ClinicalTrials.gov ID: NCT07473700
What this study is testing
What is TX000045?
TX000045 is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for hypertension, pulmonary.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The primary purpose of this study is to assess the effect of TX000045 on pulmonary vascular resistance (PVR) in participants with pulmonary hypertension secondary to interstitial lung disease (PH-ILD) and to assess the safety and tolerability of TX000045 in participants with PH-ILD.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Confirmed diagnosis of ILD based on imaging: chest computed tomography (CT) performed within the past 12 months with fibrotic lung disease (greater...
- 40% predicted less than or equal to (\<=) forced vital capacity (FVC) \<= 80% predicted at screening
- At least ONE of the following is required to undergo the first screening visit: Documented diagnostic right heart catheterization (RHC) within 18...
You likely can't join if
- Participants have a confirmed or suspected diagnosis of pulmonary hypertension in World Health Organization (WHO) Group 1, WHO Group 2, WHO Group 4...
- Participants have received phosphodiesterase type 5 inhibitors, endothelin receptor antagonists, soluble guanylate cyclase stimulators, intravenous...
- Participants have any type of pulmonary and cardiovascular comorbidities as defined n protocol
- Participants who are taking disease-modifying therapy for the underlying interstitial lung disease (ILD) (anti-fibrotics, immunosuppressives, and...
The study team makes the final eligibility decision.
Where it's taking place
- Phoenix, Arizona, United States
- San Francisco, California, United States
- Idaho Falls, Idaho, United States
- Allen Park, Michigan, United States
- Krakow, Poland
- Lublin, Poland
- Wroclaw, Poland
- Bucharest, Romania
- Belgrade, Serbia
- Kamenitz, Serbia
- Niš, Serbia
- Gyeonggi-do, South Korea
- Seoul, South Korea
- Barcelona, Spain
- Madrid, Spain
- Santander, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Phoenix, Arizona, United States; San Francisco, California, United States; Idaho Falls, Idaho, United States; Allen Park, Michigan, United States; Krakow, Poland; Lublin, Poland and 10 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.