Recurrent Parathyroid Carcinoma study: Ultrasound-guided RFA
Official title Radiofrequency Ablation For Recurrent Parathyroid Carcinoma
ClinicalTrials.gov ID: NCT07475780
What this study is testing
- What it's testing
- The study aims to see if the procedure can lower high calcium levels in these patients.
- Who it's for
- Patients who have had surgery for parathyroid carcinoma, now have a recurrent tumor seen on ultrasound and have uncontrolled high calcium.
- What's involved
- Participants will receive ultrasound‑guided radiofrequency ablation of the recurrent tumor.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patients with recurrent parathyroid carcinoma that was previously resected and persistent or recurrent hypercalciemia.
You likely can't join if
- Patient is older than 18 years, is not a surgical candidate or refuses to have surgery.
- Patient is medically fit to undergo local anesthesia with or without conscious sedation.
- Patient is able to understand and give consent to participation in the study.
- Confirmed parathyroid carcinoma by prior surgery and histopathology.
- Presence of local recurrence or implant in the neck visible on ultrasound.
- Distant oligometastasis visible on ultrasound.
See the full eligibility criteria
- Adult patients with recurrent parathyroid carcinoma that was previously resected and persistent or recurrent hypercalciemia. Patients are not surgical candidates or strongly desire nonsurgical intervention.
- Patient is older than 18 years, is not a surgical candidate or refuses to have surgery.
- Patient is medically fit to undergo local anesthesia with or without conscious sedation.
- Patient is able to understand and give consent to participation in the study.
- Confirmed parathyroid carcinoma by prior surgery and histopathology.
- Presence of local recurrence or implant in the neck visible on ultrasound.
- Distant oligometastasis visible on ultrasound.
- Solid nodule without macrocalcification or internal cystic degeneration
- Patient who is off of Cinacalcet
- Entirety of the selected nodule is visible on ultrasound without significant extension posterior to trachea or mediastinal component (ie Type A, E, or high F).
- Selected nodule is amenable to medial or lateral approach.
- Normal complete blood count, blood coagulation.
- Patient agrees to participate in the clinical study and to complete all required visits and evaluations.
- Patients with cardiac arrhythmia and/or implanted cardiac device
- Surgically naïve parathyroid lesions, parathyroid adenoma or atypical parathyroid tumor.
- Pregnancy
- Allergies to medications for anesthesia.
- Cystic nodules (\< 70% solid components)
- Calcified nodules
- Targeted nodule within 0.5 cm from the major vessels, vagus nerve, brachial plexus, and recurrent laryngeal nerve.
- Patients with contralateral vocal cord paralysis.
- Uncorrectable coagulopathy with PTT\>1.5 X ULN or INR \>1.5 or platelet count \<100,000 per mm3
The study team makes the final eligibility decision.
Where it is enrolling
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Houston, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.