Chemotherapy-induced Peripheral Neuropathy study: EX-CIPN
Official title Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)
ClinicalTrials.gov ID: NCT07481149
What this study is testing
- What it's testing
- The study wants to find out whether the EX‑CIPN exercise program reduces symptoms and disability from chemotherapy‑induced peripheral neuropathy compared with usual care.
- Who it's for
- Cancer survivors who still have persistent nerve pain or tingling after chemotherapy are eligible.
- What's involved
- Participants will either do a 10‑week remote, personalized exercise program with health‑coach calls and wear a FitBit, or receive usual care. All will complete questionnaires at the start, after the program, and three months later; the exercise group also has a 6‑month follow‑up.
- Time commitment
- The study lasts about 6 months with visits (online assessments) at baseline, after 10 weeks, at 3 months, and for the exercise group at 6 months.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- diagnosed with any type of cancer
- received chemotherapy treatment as part of curative-intent therapy (no minimum dose)
- \>6 months following chemotherapy completion with no current plans for further chemotherapy
- report Grade 1 or higher on the numbness and tingling severity item of the Common Terminology Criteria for Adverse Events (CTCAE) v 5.0
- neuropathic pain 3 or higher on the Neuropathic Pain 4 (DN4) (interview)
You likely can't join if
- currently meeting all recommendations from the physical activity guidelines for cancer survivors
- have any neurological conditions influencing cognition (i.e. dementia, Alzheimer's) and preventing safe or appropriate engagement with exercise...
- have neuropathy that pre-existed chemotherapy receipt (i.e. diabetic neuropathy)
- currently enrolled in other rehabilitation or exercise-based interventions
See the full eligibility criteria
- diagnosed with any type of cancer
- received chemotherapy treatment as part of curative-intent therapy (no minimum dose)
- \>6 months following chemotherapy completion with no current plans for further chemotherapy
- report Grade 1 or higher on the numbness and tingling severity item of the Common Terminology Criteria for Adverse Events (CTCAE) v 5.0
- neuropathic pain 3 or higher on the Neuropathic Pain 4 (DN4) (interview)
- capable of ambulation and transfers (with or without gait/transfer aid) (ECOG score 0-2)
- are able to communicate sufficiently in English to complete intervention, questionnaires, and consent
- have access to and able to operate videoconferencing
- currently meeting all recommendations from the physical activity guidelines for cancer survivors
- have any neurological conditions influencing cognition (i.e. dementia, Alzheimer's) and preventing safe or appropriate engagement with exercise recommendation
- have neuropathy that pre-existed chemotherapy receipt (i.e. diabetic neuropathy)
- currently enrolled in other rehabilitation or exercise-based interventions
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.