Chronic Low Back Pain study: Physical Exercise
Official title Neuroimmune Responses to Exercise in Chronic Back Pain
ClinicalTrials.gov ID: NCT07497425
What this study is testing
- What it's testing
- The study aims to learn how exercise affects the body and brain in people with chronic low back pain. It also looks at immune activity and brain function compared to healthy people.
- Who it's for
- The study is looking for people who have chronic low back pain.
- What's involved
- Participants will follow a 12-week online exercise program. They will also fill out questionnaires, give blood samples, and have brain scans.
- Time commitment
- The study lasts 12 weeks and requires visits for blood tests and brain imaging.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Have a diagnosis of chronic primary LBP, according to the criteria established by NIH Task Force on Research Standards for CLBP (Deyo et al., 2015).
- Report a CLBP intensity of at least 4 in a 0-10 numerical rating scale (0 = no pain, 10 = maximum possible pain).
You likely can't join if
- Present any red flags indicative of serious pathology comorbid or as the cause of CLBP (Finucane et al., 2020);
- Have a CLBP phenotype characterized by predominant nociceptive (as in fracture, infection, malignancy, inflammatory or rheumatic spondyloarthropathy...
- Present chronic or acute pain of higher intensity or perceived disability in any other body site than the low back;
- Medical history of diabetes, neurological or psychiatric disorder;
- Presence of significant cardiorespiratory problems or any other potential contraindications to physical exercise as assessed through the Physical...
- Following a regular structured PE training program (\>60 min/week) at study's onset, and;
See the full eligibility criteria
- Have a diagnosis of chronic primary LBP, according to the criteria established by NIH Task Force on Research Standards for CLBP (Deyo et al., 2015).
- Report a CLBP intensity of at least 4 in a 0-10 numerical rating scale (0 = no pain, 10 = maximum possible pain). -Healthy controls: \- Be over 18 years and under 75 years of age;
- Present any red flags indicative of serious pathology comorbid or as the cause of CLBP (Finucane et al., 2020);
- Have a CLBP phenotype characterized by predominant nociceptive (as in fracture, infection, malignancy, inflammatory or rheumatic spondyloarthropathy, cauda equina syndrome, confirmed by MRI when suspected) or...
- Present chronic or acute pain of higher intensity or perceived disability in any other body site than the low back;
- Medical history of diabetes, neurological or psychiatric disorder;
- Presence of significant cardiorespiratory problems or any other potential contraindications to physical exercise as assessed through the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+);
- Following a regular structured PE training program (\>60 min/week) at study's onset, and;
- Have symptoms or a diagnosis of any acute or chronic pain conditions;
- Medical history of diabetes, neurological or psychiatric disorder;
- Presence of significant cardiorespiratory problems or any other potential contraindications to physical exercise as assessed through the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+);
- Following a regular structured PE training program (\>60 min/week) at study's onset, and;
- Presence of any contraindications to MRI examination (including any metallic implants or devices, being pregnant, and claustrophobia).
The study team makes the final eligibility decision.
Where it is enrolling
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Montreal, Quebec, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.