Obesity study: NNC0487-0111
Official title AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
ClinicalTrials.gov ID: NCT07509307
What this study is testing
What is NNC0487-0111?
NNC0487-0111 is an investigational medicine, given as a once-weekly injection under the skin, being studied as a potential treatment for obesity.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study is checking whether NNC0487-0111 is safe and whether it helps reduce weight and knee pain compared with a placebo.
- Who it's for
- Adults who have excess body weight and knee osteoarthritis.
- What's involved
- Participants will receive an injection under the skin once a week, either the study drug or a placebo, and will have study visits for monitoring.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female (sex at birth)
- Age 18 years or above at the time of signing the informed consent
- Clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence [KL] grades 2...
- Symptomatic knee OA with first appearance of pain in the target knee \> 90 days prior to screening and pain in the target knee for \> 15 days over...
- Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC)...
You likely can't join if
- Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based...
- Any joint prosthesis or joint replacement in target knee
- Arthroscopy or injections into target knee within the last 90 days prior to screening
- Any other joint disease in target knee including gout and pseudogout
The study team makes the final eligibility decision.
Where it is enrolling
- Escondido, California, United States
- Lancaster, California, United States
- Palm Springs, California, United States
- Waterbury, Connecticut, United States
- Jacksonville, Florida, United States
- Naples, Florida, United States
- Gurnee, Illinois, United States
- Skokie, Illinois, United States
- Louisville, Kentucky, United States
- Troy, Michigan, United States
- Springfield, Missouri, United States
- New York, New York, United States
- Statesville, North Carolina, United States
- Portland, Oregon, United States
- Dallas, Texas, United States
- Newport News, Virginia, United States
- Bellevue, Washington, United States
- Botany, New South Wales, Australia
- Darlinghurst, New South Wales, Australia
- St Leonards, New South Wales, Australia
+ 41 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Escondido, California, United States; Lancaster, California, United States; Palm Springs, California, United States; Waterbury, Connecticut, United States; Jacksonville, Florida, United States; Naples, Florida, United States and 55 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.