Solid Tumors study: INCB161734
Official title A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
ClinicalTrials.gov ID: NCT07522073
What this study is testing
What is INCB161734?
an investigational oral tablet being studied as a potential treatment for metastatic pancreatic ductal adenocarcinoma in combination with standard chemotherapy
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether adding INCB161734 to standard chemotherapy improves how well it works and how safe it is for people with metastatic pancreatic cancer.
- Who it's for
- You may be able to join if you have metastatic pancreatic cancer and have not had chemotherapy before.
- What's involved
- You will receive standard chemotherapy, and some of you will also get INCB161734. You will have regular visits and tests to check your health.
- Time commitment
- The study lasts about 6 months, with visits every few weeks to monitor your progress.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Histologically or cytologically confirmed metastatic PDAC with a KRAS G12D mutation
- No prior systemic treatment in the metastatic setting
- ECOG Performance status 0-1
- Adequate organ function
You likely can't join if
- Prior treatment with any KRAS inhibitor
- Chronic or current active infection requiring systemic treatment within 1 week prior to the first dose of study drug
- Known active CNS metastases Other protocol-defined Inclusion/Exclusion Criteria may apply.
The study team makes the final eligibility decision.
Where it is enrolling
- Anchorage, Alaska, United States
- Chandler, Arizona, United States
- Duarte, California, United States
- Los Angeles, California, United States
- Orange, California, United States
- San Francisco, California, United States
- Santa Monica, California, United States
- Denver, Colorado, United States
- Fort Myers, Florida, United States
- Miami, Florida, United States
- St. Petersburg, Florida, United States
- West Palm Beach, Florida, United States
- Atlanta, Georgia, United States
- Evanston, Illinois, United States
- Naperville, Illinois, United States
- Springfield, Illinois, United States
- New Orleans, Louisiana, United States
- Boston, Massachusetts, United States
- Detroit, Michigan, United States
- Grand Rapids, Michigan, United States
+ 92 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Anchorage, Alaska, United States; Chandler, Arizona, United States; Duarte, California, United States; Los Angeles, California, United States; Orange, California, United States; San Francisco, California, United States and 106 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.