Alopecia Areata study: LY4005130
Official title A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
ClinicalTrials.gov ID: NCT07533006
What this study is testing
What is LY4005130?
an investigational IV medicine being studied as a potential treatment for severe alopecia areata
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see if LY4005130 works better than placebo and to assess its safety and side effects. It also looks at how the drug is processed in the body.
- Who it's for
- Adults who have severe alopecia areata.
- What's involved
- Participants will receive an IV infusion of LY4005130 or a placebo and will have blood tests to monitor the drug and its effects.
- Time commitment
- The trial lasts about 48 weeks total, including screening, with regular visits for infusions and testing.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Hair loss encompassing ≥50% and ≤90% of the scalp, as measured by Severity of Alopecia Tool (SALT) score
- The duration of the current episode of severe AA is at least 6 months and does not exceed 4 years
- No significant spontaneous hair regrowth in the investigator's opinion for at least 6 months
- Agree not to use any AA treatments during the study
You likely can't join if
- Primarily "diffuse" type of AA (characterized by diffuse hair shedding)
- Are currently experiencing other forms of alopecia
- Participants who, in the opinion of the investigator, are currently experiencing or have a history of unstable concomitant disease that requires...
- Have had any major surgery within 8 weeks prior to screening or will require major surgery during the study
- Have a history or presence of cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, hematological, neurological, or neuropsychiatric...
The study team makes the final eligibility decision.
Where it is enrolling
- Fremont, California, United States
- Northridge, California, United States
- Santa Clarita, California, United States
- Cutler Bay, Florida, United States
- Boston, Massachusetts, United States
- Troy, Michigan, United States
- Portsmouth, New Hampshire, United States
- San Antonio, Texas, United States
- South Jordan, Utah, United States
- Kelowna, Canada
- Newmarket, Canada
- Ottawa, Canada
- Verdun, Canada
- Beijing, China
- Shanghai, China
- Tianjin, China
- Rotterdam, Netherlands
- Gdansk, Poland
- Krakow, Poland
- Ostrowiec Świętokrzyski, Poland
+ 7 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Fremont, California, United States; Northridge, California, United States; Santa Clarita, California, United States; Cutler Bay, Florida, United States; Boston, Massachusetts, United States; Troy, Michigan, United States and 21 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.