Huntington's Disease study: SRP-1005
Official title A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease
ClinicalTrials.gov ID: NCT07536061
What this study is testing
What is SRP-1005?
This is an investigational medicine being studied as a potential treatment for Huntington's disease.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether SRP-1005 is safe and how it affects Huntington’s disease.
- Who it's for
- You may be able to join if you have Huntington’s disease and meet the study’s health criteria.
- What's involved
- You will receive SRP-1005 and have regular check‑ins and tests to track your health.
- Time commitment
- The study lasts several weeks and includes multiple visits for monitoring.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 70
You may be able to join if
- Genetically confirmed diagnosis of huntingtin (HTT) cytosine-adenine-guanine repeat length ≥40.
- Participant has HD Integrated Staging System (HD-ISS) Stage 2 or Mild Stage 3.
- Participants who are of childbearing potential, or with partners of childbearing potential, who are sexually active must agree to use a highly...
You likely can't join if
- Any condition that would compromise the safety or feasibility of lumbar puncture or magnetic resonance imaging (MRI).
- Presence of other significant neurological or systemic illnesses.
- Current, chronic or active human immunodeficiency virus, hepatitis B/C.
- Recent use of investigational agents or HTT-lowering therapies.
- Uncontrolled psychiatric illness or substance use disorders.
- Pregnancy or lactation. Note: Other inclusion/exclusion criteria apply.
The study team makes the final eligibility decision.
Where it is enrolling
- Westmead, New South Wales, Australia
- Parkville, Victoria, Australia
- Christchurch, New Zealand
- Gümligen, Canton of Bern, Switzerland
- Cardiff, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Westmead, New South Wales, Australia; Parkville, Victoria, Australia; Christchurch, New Zealand; Gümligen, Canton of Bern, Switzerland; Cardiff, United Kingdom. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.