Myofascial Pain Dysfunction Syndrome study: PRP plus Betamethasone vs Betamethasone
Official title PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain
ClinicalTrials.gov ID: NCT07547605
What this study is testing
What is PRP plus Betamethasone?
An investigational injection being studied as a potential treatment for myofascial pain dysfunction syndrome. It is designed to combine growth‑factor release from platelet‑rich plasma with anti‑inflammatory effects of betamethasone to support tissue healing and reduce pain.
Also referred to as Diprospan (betamethasone dipropionate and betamethasone sodium phosphate).
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The trial aims to find out which injection, platelet‑rich plasma (PRP) alone, PRP plus a steroid, or steroid alone, gives the best pain relief after three months.
- Who it's for
- Adults who have one painful spot in the upper trapezius muscle and have not improved with other treatments.
- What's involved
- Participants receive one injection of the assigned treatment. They will have follow‑up visits at 1 week, 4 weeks, 3 months, and 6 months for pain and function tests, and to record any side effects.
- Time commitment
- The study lasts six months, with visits at 1 week, 4 weeks, 3 months, and 6 months after the injection.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Age between 18 and 65 years
- Presentation to the Orthopedics and Traumatology outpatient clinic with neck and/or shoulder pain
- Presence of a taut band
- Local tenderness
- Referred pain pattern
You likely can't join if
- Presence of multiple active trigger points
- Diagnosis of fibromyalgia according to ACR 2010 criteria
- Cervical radiculopathy or myelopathy
- Trigger point injection in the same region within the past 3 months
- Coagulopathy or current anticoagulant or antiplatelet therapy
- Known allergy or contraindication to corticosteroids, local anesthetics, or PRP components
See the full eligibility criteria
- Age between 18 and 65 years
- Presentation to the Orthopedics and Traumatology outpatient clinic with neck and/or shoulder pain
- Presence of a taut band
- Local tenderness
- Referred pain pattern
- Local twitch response
- Presence of a single active trigger point in the upper trapezius muscle
- Symptom duration ≥ 4 weeks
- Pain intensity ≥ 4 on the visual analog scale (VAS)
- Inadequate response to at least 4 weeks of conservative treatment (physical therapy and/or oral analgesics)
- Ability to provide written informed consent
- Presence of multiple active trigger points
- Diagnosis of fibromyalgia according to ACR 2010 criteria
- Cervical radiculopathy or myelopathy
- Trigger point injection in the same region within the past 3 months
- Coagulopathy or current anticoagulant or antiplatelet therapy
- Known allergy or contraindication to corticosteroids, local anesthetics, or PRP components
- Active infection (systemic or local)
- Pregnancy or lactation
- Thrombocytopenia (platelet count \< 100,000/µL)
- Malignancy
- Inability to cooperate or provide informed consent
The study team makes the final eligibility decision.
Where it is enrolling
- Kyrenia, Keryneia, Cyprus
- Kyrenia, Cyprus
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Kyrenia, Keryneia, Cyprus; Kyrenia, Cyprus. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.