Trial comparing treatments for Metastatic Colorectal Cancer
Official title A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
ClinicalTrials.gov ID: NCT07549412
What this study is testing
What is Precemtabart tocentecan?
An investigational intravenous medicine being studied as a potential treatment for metastatic colorectal cancer.
Also referred to as Precem-TcT.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether a new drug mix works better than a standard mix. It looks at how long people live with the new treatment.
- Who it's for
- You may be able to join if you have colon cancer that has spread. You must have tried certain other drugs before.
- What's involved
- You would get one of two drug mixes. You would also get regular check-ups and tests.
- Time commitment
- The study lasts until the cancer grows or you stop taking part.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Participants with documented histopathological diagnosis of metastatic colorectal cancer, who were intolerant to, or whose disease was refractory to...
- Participants must have received and progressed on no more than 2 previous systemic treatment regimens in the metastatic setting
- Eastern Cooperative Oncology Group (ECOG) performance status less than equal to 1
- Participants must be able to swallow oral tablets, and to comply with the study requirements for all scheduled evaluations
- Other protocol defined may apply
You likely can't join if
- If Adverse Events related to previous therapies have not recovered to less than Grade 1 by National Cancer Institute - Common Terminology Criteria...
- Participant has a history of additional malignancy within 3 years before randomization
- Participants with known brain metastases
- Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months prior to randomization
- Participants with ileus of more than Grade 1, or chronic inflammatory bowel disease (example ulcerative colitis, Crohn's disease) and/or bowel...
- Other protocol defined exclusion criteria may apply
The study team makes the final eligibility decision.
Where it is enrolling
- San Francisco, California, United States
- Lone Tree, Colorado, United States
- Fort Myers, Florida, United States
- St. Petersburg, Florida, United States
- West Palm Beach, Florida, United States
- Arlington Heights, Illinois, United States
- Peoria, Illinois, United States
- Springfield, Illinois, United States
- Sterling Heights, Michigan, United States
- Saint Louis Park, Minnesota, United States
- Columbia, Missouri, United States
- White Plains, New York, United States
- Greenville, South Carolina, United States
- Sioux Falls, South Dakota, United States
- Nashville, Tennessee, United States
- Abilene, Texas, United States
- Austin, Texas, United States
- Bedford, Texas, United States
- San Antonio, Texas, United States
- Tyler, Texas, United States
+ 80 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at San Francisco, California, United States; Lone Tree, Colorado, United States; Fort Myers, Florida, United States; St. Petersburg, Florida, United States; West Palm Beach, Florida, United States; Arlington Heights, Illinois, United States and 94 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.