Obesity study: NNC0487-0111
Official title AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
ClinicalTrials.gov ID: NCT07571109
What this study is testing
What is NNC0487-0111?
An investigational once‑weekly injectable medicine being studied for obesity and obstructive sleep apnoea.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether the medicine NNC0487-0111 can help people with excess weight and sleep apnea lose weight and improve sleep. It also looks at how safe the medicine is.
- Who it's for
- You may be able to join if you are overweight or obese and have sleep apnea that is treated with a breathing machine.
- What's involved
- You will receive a small injection under the skin once a week. Some people get the medicine, others get a pretend treatment, chosen by chance.
- Time commitment
- The study lasts several weeks, with weekly injections and regular check‑ins to monitor your health.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female (sex at birth)
- Age 18 years or above at the time of signing informed consent
- Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method...
You likely can't join if
- Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records
- Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and...
- Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based...
The study team makes the final eligibility decision.
Where it is enrolling
- Gilbert, Arizona, United States
- Bradenton, Florida, United States
- Naples, Florida, United States
- West Palm Beach, Florida, United States
- Atlanta, Georgia, United States
- Lawrenceville, Georgia, United States
- Chicago, Illinois, United States
- New York, New York, United States
- Fargo, North Dakota, United States
- Cincinnati, Ohio, United States
- Columbia, South Carolina, United States
- DeSoto, Texas, United States
- El Paso, Texas, United States
- Houston, Texas, United States
- San Antonio, Texas, United States
- Sugar Land, Texas, United States
- Renton, Washington, United States
- Seattle, Washington, United States
- Macquarie Park, New South Wales, Australia
- Birtinya, Queensland, Australia
+ 52 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Gilbert, Arizona, United States; Bradenton, Florida, United States; Naples, Florida, United States; West Palm Beach, Florida, United States; Atlanta, Georgia, United States; Lawrenceville, Georgia, United States and 66 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.