Clinical trial for Ischemic Stroke
Official title Connectomic Alterations Following Acute Ischemic Stroke in the MCA Territory
ClinicalTrials.gov ID: NCT07584681
What this study is testing
- What it's testing
- This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age \> 18 years;
- Diagnosis of acute ischemic stroke with confirmed occlusion of the M1 or more distal MCA territory.
- Received reperfusion therapy via mechanical thrombectomy or IV thrombolytics(Tenecteplase, or Alteplase).
- Presence of a motor deficit on initial clinical exam (e.g., NIHSS \> 0) and on immediate post-intervention exam.
- Patients or health-care proxy must be able to provide informed consent.
You likely can't join if
- Age \< 17 years;
- Large vessel occlusions proximal to M1 (e.g., ICA), completed M1 occlusions.
- Pre-stroke Modified Rankin Scale score ≥ 3
- Known neurodegenerative disease or prior stroke affecting motor pathways.
- Inability to undergo MRI due to cardiac pacemaker, claustrophobia, and metal implants that cannot be removed prior to MRI.
- Pregnancy. Because of potential risk of serial MRI to fetus, women of child-bearing age require a pregnancy test at screening and agree to...
See the full eligibility criteria
- Age \> 18 years;
- Diagnosis of acute ischemic stroke with confirmed occlusion of the M1 or more distal MCA territory.
- Received reperfusion therapy via mechanical thrombectomy or IV thrombolytics(Tenecteplase, or Alteplase).
- Presence of a motor deficit on initial clinical exam (e.g., NIHSS \> 0) and on immediate post-intervention exam.
- Patients or health-care proxy must be able to provide informed consent.
- Must be able to undergo sequential MRI at Lenox Hill Hospital, including resting-state fMRI (rs-fMRI) and diffusion MRI (dMRI) for, respectively, functional, and structural connectomic analyses.
- Age \< 17 years;
- Large vessel occlusions proximal to M1 (e.g., ICA), completed M1 occlusions.
- Pre-stroke Modified Rankin Scale score ≥ 3
- Known neurodegenerative disease or prior stroke affecting motor pathways.
- Inability to undergo MRI due to cardiac pacemaker, claustrophobia, and metal implants that cannot be removed prior to MRI.
- Pregnancy. Because of potential risk of serial MRI to fetus, women of child-bearing age require a pregnancy test at screening and agree to contraceptive practices during the study.
- Poor image quality or incomplete imaging datasets.
The study team makes the final eligibility decision.
Where it is enrolling
- New York, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at New York, New York, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.