Major Depressive Disorder study: DT120
Official title A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
ClinicalTrials.gov ID: NCT07592689
What this study is testing
What is DT120?
DT120 is an investigational psychoactive drug being studied as a potential treatment for major depressive disorder. DT120 is designed to act as an agonist at the serotonin 2A (5-HT2A) receptor.
Also referred to as MM120, lysergide tartrate.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether DT120 helps people with major depression. It compares DT120 to a pretend treatment.
- Who it's for
- You may be able to join if you have major depression and meet the study’s health criteria.
- What's involved
- You will receive either DT120 or a pretend treatment. You will visit the clinic for check‑ins and give information about how you feel.
- Time commitment
- The study lasts about 6 weeks for the main part, with extra visits if you stay in the open‑label extension.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 74
You may be able to join if
- Diagnosis of MDD per DSM-5
- Male or female aged 18 to 74
- Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration
- MADRS Total Score ≥26
- CGI-S Score ≥4
You likely can't join if
- Certain psychiatric disorders (other than major depressive disorder)
- First degree relative with or lifetime history of a psychotic disorder or bipolar disorder
- Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine
- Any clinically significant unstable illness
The study team makes the final eligibility decision.
Where it is enrolling
- Little Rock, Arkansas, United States
- Orange, California, United States
- San Diego, California, United States
- Santa Monica, California, United States
- Denver, Colorado, United States
- Jacksonville, Florida, United States
- Maitland, Florida, United States
- Orlando, Florida, United States
- Tampa, Florida, United States
- Atlanta, Georgia, United States
- Decatur, Georgia, United States
- Savannah, Georgia, United States
- Chicago, Illinois, United States
- Boston, Massachusetts, United States
- Worcester, Massachusetts, United States
- St Louis, Missouri, United States
- Las Vegas, Nevada, United States
- Philadelphia, Pennsylvania, United States
- North Charleston, South Carolina, United States
- Austin, Texas, United States
+ 3 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 74 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Little Rock, Arkansas, United States; Orange, California, United States; San Diego, California, United States; Santa Monica, California, United States; Denver, Colorado, United States; Jacksonville, Florida, United States and 17 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.