Rhinovirus Infection study: VPV
Official title Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
ClinicalTrials.gov ID: NCT07610395
What this study is testing
What is VPV 1000 mg?
An investigational oral medicine being studied as a potential treatment for rhinovirus infection in people with COPD. It is designed to bind to the viral capsid and prevent the virus from replicating inside cells.
Also referred to as Vapendavir.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out how safe the drug is and whether it reduces the severity or length of respiratory symptoms caused by rhinovirus infection in COPD patients.
- Who it's for
- Adults who have chronic obstructive pulmonary disease (COPD) and become infected with the common cold virus (rhinovirus).
- What's involved
- Participants will take an oral dose of vapendavir (one of two strengths) or a placebo and will have safety checks and symptom monitoring during the illness.
- Time commitment
- Participants will be followed for the duration of their illness with scheduled clinic visits to assess safety and symptoms.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 85
You may be able to join if
- Inclusion Sign informed consent for study participation and medical records release (if needed).
- Increase frequency or dose of beta agonist(s), oxygen, breathing treatments or chronic COPD medications (Mild Exacerbation)
- Use of oral or systemic steroids (Moderate Exacerbation), or
- Use of Antibiotics (Moderate Exacerbation), or
- Chronic oral/systemic steroids \>10 mg per day (inhaled corticosteroids are permitted).
You likely can't join if
- It is already determined, based on the Investigator's clinical judgement, that the participant will likely need antibiotics and/or oral steroids at...
- On or within 7 days prior to randomization, there is another active diagnosed infection with viral or bacterial pathogens (i.e., urinary tract...
See the full eligibility criteria
- Inclusion Sign informed consent for study participation and medical records release (if needed). Male or female age ≥40 years and ≤85 years at the time of signing the informed consent at Screening.
- Increase frequency or dose of beta agonist(s), oxygen, breathing treatments or chronic COPD medications (Mild Exacerbation)
- Use of oral or systemic steroids (Moderate Exacerbation), or
- Use of Antibiotics (Moderate Exacerbation), or
- Chronic oral/systemic steroids \>10 mg per day (inhaled corticosteroids are permitted).
- Continuous oxygen via nasal cannula of \>2 L/min at the time of Screening or during the Asymptomatic Phase.
- It is already determined, based on the Investigator's clinical judgement, that the participant will likely need antibiotics and/or oral steroids at the Day 1 Randomization Visit.
- On or within 7 days prior to randomization, there is another active diagnosed infection with viral or bacterial pathogens (i.e., urinary tract infection, cellulitis, etc.) that requires treatment.
The study team makes the final eligibility decision.
Where it is enrolling
- Mobile, Alabama, United States
- Newport Beach, California, United States
- San Diego, California, United States
- Bradenton, Florida, United States
- Miami Lakes, Florida, United States
- Tamarac, Florida, United States
- East Point, Georgia, United States
- Naperville, Illinois, United States
- Valparaiso, Indiana, United States
- Lutherville, Maryland, United States
- Dearborn, Michigan, United States
- Troy, Michigan, United States
- Hamilton, New Jersey, United States
- Binghamton, New York, United States
- Brooklyn, New York, United States
- Kings Mountain, North Carolina, United States
- Columbus, Ohio, United States
- Milford, Ohio, United States
- Edmond, Oklahoma, United States
- Medford, Oregon, United States
+ 13 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Mobile, Alabama, United States; Newport Beach, California, United States; San Diego, California, United States; Bradenton, Florida, United States; Miami Lakes, Florida, United States; Tamarac, Florida, United States and 27 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.