Nicotine Dependence study: Oral Nicotine Pouch vs Smoking Cue Reactivity Task
Official title Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
ClinicalTrials.gov ID: NCT07698470
What this study is testing
- What it's testing
- The study wants to see whether using a nicotine pouch lowers how much people crave cigarettes and how their brain reacts to smoking images.
- Who it's for
- Adults who smoke cigarettes and are willing to try a nicotine pouch.
- What's involved
- Participants will use one 6 mg nicotine pouch after staying overnight without nicotine, then answer questions about craving and have their brain activity measured with a near‑infrared scanner while looking at smoking pictures.
- Time commitment
- The study lasts a few hours on one day, with a few visits for assessments before and after the pouch.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 55. Healthy volunteers may be eligible.
You may be able to join if
- Age 21 years - 55 years
- Self-reported use of cigarettes within the past 30 days
- Biochemical confirmation of cigarette use: o Carbon monoxide (CO) breath sample ≥10 ppm
- Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine dependence
- Fluent in English
You likely can't join if
- Age younger than 21 years or older than 55 years
- Biochemical evidence inconsistent with recent cigarette use: o CO breath sample \<10 ppm
- Expressed intent to reduce or quit nicotine use within the next 30 days
- History of medical conditions contraindicated for nicotine use (e.g., uncontrolled hypertension, recent cardiac events)
- Primary use of non-cigarette products (e.g., cigars, pipe tobacco, smokeless tobacco)
- Prior use of oral nicotine products in their lifetime
See the full eligibility criteria
- Age 21 years - 55 years
- Self-reported use of cigarettes within the past 30 days
- Biochemical confirmation of cigarette use: o Carbon monoxide (CO) breath sample ≥10 ppm
- Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine dependence
- Fluent in English
- Willing to try an oral nicotine pouch
- Willing to abstain from nicotine for at least 12 hours prior to each experimental session
- Age younger than 21 years or older than 55 years
- Biochemical evidence inconsistent with recent cigarette use: o CO breath sample \<10 ppm
- Expressed intent to reduce or quit nicotine use within the next 30 days
- History of medical conditions contraindicated for nicotine use (e.g., uncontrolled hypertension, recent cardiac events)
- Primary use of non-cigarette products (e.g., cigars, pipe tobacco, smokeless tobacco)
- Prior use of oral nicotine products in their lifetime
The study team makes the final eligibility decision.
Where it is enrolling
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 55 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Los Angeles, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.