Overweight study: Zenagamtide
Official title AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
ClinicalTrials.gov ID: NCT07720271
What this study is testing
What is zenagamtide?
An investigational oral tablet being studied for treating overweight.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether zenagamtide is safe and works for people who are overweight or obese.
- Who it's for
- You may be able to join if you are an adult with excess body weight and are not taking other weight‑loss medicines.
- What's involved
- You will take one tablet by mouth each day. Some people get the real drug, others get a pretend treatment. You will have check‑ins to see how you feel and how much weight you lose.
- Time commitment
- The study lasts about 12 weeks, with regular visits to the clinic for check‑ins and measurements.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female (sex at birth).
- Age 18 and older (both inclusive) at time of signing the informed consent.
You likely can't join if
- Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% [48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
- Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based...
The study team makes the final eligibility decision.
Where it is enrolling
- Anniston, Alabama, United States
- Birmingham, Alabama, United States
- Montgomery, Alabama, United States
- Fullerton, California, United States
- Lomita, California, United States
- Walnut Creek, California, United States
- Aurora, Colorado, United States
- Delray Beach, Florida, United States
- Fleming Island, Florida, United States
- Hialeah, Florida, United States
- Jacksonville, Florida, United States
- Miramar, Florida, United States
- Orlando, Florida, United States
- Oviedo, Florida, United States
- Conyers, Georgia, United States
- Honolulu, Hawaii, United States
- Chicago, Illinois, United States
- Gurnee, Illinois, United States
- Skokie, Illinois, United States
- Buckley, Michigan, United States
+ 17 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Anniston, Alabama, United States; Birmingham, Alabama, United States; Montgomery, Alabama, United States; Fullerton, California, United States; Lomita, California, United States; Walnut Creek, California, United States and 31 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.