Asthma study: JNJ-95597528
Official title A Study of JNJ-95597528 in Participants With Inadequately Controlled Moderate to Severe Asthma
ClinicalTrials.gov ID: NCT07746687
What this study is testing
What is JNJ-95597528?
JNJ-95597528 is an investigational once‑daily subcutaneous injection being studied for moderate to severe asthma.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether JNJ-95597528 helps adults with moderate to severe asthma better than a pretend treatment.
- Who it's for
- You may be able to join if you are an adult with moderate to severe asthma that is not well controlled.
- What's involved
- You will receive either the medicine or a pretend treatment. You will have visits and tests to check your breathing and health.
- Time commitment
- The study lasts several weeks and includes multiple visits to the clinic for check‑ins and tests.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Medically stable on the basis of physical examination, medical history, and vital signs performed at screening or at baseline
- Confirmed variable expiratory flow (1 or more of the following) per global initiative for asthma (GINA) 2025 at the baseline visit: a.
- Inhaled corticosteroid: Prescribed medium- or high-dose ICS for at least 1 year and a stable dose of medium- or high-dose ICS for at least 3 months...
- Additional controller medication: Must be on a stable dose of at least 1 additional maintenance asthma controller, in addition to ICS, per GINA 2025...
- Asthma control questionnaire, 5-item (ACQ-5) score \>=1.5 at the screening visit and the baseline visit
You likely can't join if
- History of uncontrolled, significant renal, cardiac, vascular, pulmonary (other than asthma), gastrointestinal, endocrine, neurologic, hematologic...
- Any clinically important pulmonary disease other than asthma or pulmonary or systemic diseases, other than asthma, that are associated with elevated...
- Experienced primary how well it works failure (no response within 16 weeks) or an adverse event (AE) requiring discontinuation related to agents...
- Participants with either of the following events within the 2 weeks prior to the screening visit: a.
- Current smokers or former smokers with a smoking history \>=20 pack-years.
The study team makes the final eligibility decision.
Where it is enrolling
- Westminster, California, United States
- Boston, Massachusetts, United States
- Minneapolis, Minnesota, United States
- St Louis, Missouri, United States
- The Bronx, New York, United States
- Edmond, Oklahoma, United States
- Oklahoma, Texas, United States
- Buenos Aires, Argentina
- Córdoba, Argentina
- Mendoza, Argentina
- Rosario, Argentina
- Santa Fe, Argentina
- Beijing, China
- Changzhou, China
- Ningbo, China
- Taiyuan, China
- Tel Aviv, Israel
- Sapporo, Japan
- Shinagawa City, Japan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Westminster, California, United States; Boston, Massachusetts, United States; Minneapolis, Minnesota, United States; St Louis, Missouri, United States; The Bronx, New York, United States; Edmond, Oklahoma, United States and 13 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.