Clinical trial for Epilepsy
Official title Outcomes After Planned Discontinuation of AntiSeizure Medication
ClinicalTrials.gov ID: NCT07750496
What this study is testing
What is Discontinue antiseizure medications?
This is an investigational study plan being studied to see if stopping one seizure medicine is a good option for people with epilepsy who have not had seizures for a while.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to see if stopping anti‑seizure medication after a period of no seizures is safe and helpful, compared to keeping the medication on.
- Who it's for
- It is looking for adults who have epilepsy and have not had a seizure for a while.
- What's involved
- Participants will either keep taking their medication or stop it under medical supervision, and will have regular check‑ups and tests to monitor seizures and side effects.
- Time commitment
- The study lasts about 12 months, with scheduled visits every few months to review health and seizure activity.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Diagnosis of epilepsy
- At least 2 years since participants most recent seizure
- At most 35% calculated 1-year post-discontinuation seizure risk, based upon the existing multivariable calculator if they are on only 1 ASM...
You likely can't join if
- Current pregnancy or planned pregnancy during the study period
- History of epilepsy surgery
- Large space-occupying radiographic lesion such as a large cortical tumor, large artery stroke, or encephalomalacia from traumatic brain injury.
- Subject has any other clinically significant conditions or circumstances that in the judgment of the investigator or treating clinician should...
See the full eligibility criteria
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Diagnosis of epilepsy
- At least 2 years since participants most recent seizure
- At most 35% calculated 1-year post-discontinuation seizure risk, based upon the existing multivariable calculator if they are on only 1 ASM, otherwise no such restriction if they are more than 1 ASM
- Willingness to adhere to the study intervention
- Taking at least 1 antiseizure medication prior to enrollment
- Current pregnancy or planned pregnancy during the study period
- History of epilepsy surgery
- Large space-occupying radiographic lesion such as a large cortical tumor, large artery stroke, or encephalomalacia from traumatic brain injury.
- Subject has any other clinically significant conditions or circumstances that in the judgment of the investigator or treating clinician should preclude study participation.
The study team makes the final eligibility decision.
Where it is enrolling
- Ann Arbor, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Ann Arbor, Michigan, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.