Obesity study: ABBV-295
Official title Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
ClinicalTrials.gov ID: NCT07752979
What this study is testing
What is ABBV-295?
An investigational once‑weekly injectable medicine being studied for weight management in people with obesity or overweight.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study compares different doses of ABBV-295 to a placebo to see if it helps people lose weight after 32 weeks.
- Who it's for
- Adults with a BMI of 30 or higher who also have weight‑related health conditions.
- What's involved
- Participants receive subcutaneous injections of ABBV‑295 or a matching placebo using pre‑filled syringes. They attend regular clinic visits for medical checks, blood tests, side‑effect monitoring, and questionnaires.
- Time commitment
- The study lasts 52 weeks, with visits at the start, during the 32‑week weight‑loss period, and at the end of the year.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- BMI ≥ 30.0 kg/m2 at Screening (BMI is calculated as weight in kg divided by the square of height measured in meters) OR
- BMI ≥ 27.0 to \< 30.0 kg/m2 at Screening (BMI is calculated as weight in kg divided by the square of height measured in meters) with at least one of...
You likely can't join if
- Self-reported change in body weight ≥ 5% within 3 months prior to Screening
- Hemoglobin A1c (HbA1c) ≥ 6.5% (48 mmol/mol) at Screening
- Fasting glucose ≥126 mg/dL (7.0 mmol/L) or random glucose test ≥ 200 mg/dL (11.1 mmol/L)
- History of type 1 or type 2 diabetes mellitus
- Treatment with any medication or product used for obesity or weight management within 180 days prior to Screening Unstable or severe cardiovascular...
- The participant has a concurrent disease, condition, or is in a situation which, in the investigator's opinion, may put the participant at...
The study team makes the final eligibility decision.
Where it is enrolling
- Pelham, Alabama, United States
- Scottsdale, Arizona, United States
- Tucson, Arizona, United States
- Concord, California, United States
- Costa Mesa, California, United States
- Greenbrae, California, United States
- Huntington Park, California, United States
- Los Angeles, California, United States
- Rolling Hills Estates, California, United States
- Santa Ana, California, United States
- Spring Valley, California, United States
- Tustin, California, United States
- Walnut Creek, California, United States
- Clearwater, Florida, United States
- Fleming Island, Florida, United States
- Jacksonville, Florida, United States
- Lake Worth, Florida, United States
- Margate, Florida, United States
- Miramar, Florida, United States
- New Port Richey, Florida, United States
+ 40 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Pelham, Alabama, United States; Scottsdale, Arizona, United States; Tucson, Arizona, United States; Concord, California, United States; Costa Mesa, California, United States; Greenbrae, California, United States and 54 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.