Pulmonary Disease, Chronic Obstructive study: Brenipatide
Official title A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov ID: NCT07759245
What this study is testing
What is Brenipatide?
This is an investigational injectable medicine being studied to see if it helps people with moderate-to-severe COPD.
Also referred to as LY3537031.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether different doses of Brenipatide are safe and work as intended in people with moderate‑to‑severe COPD.
- Who it's for
- You may be able to join if you are an adult with moderate‑to‑severe COPD.
- What's involved
- You will receive Brenipatide or a pretend treatment. You will have visits and tests to check safety and how well it works.
- Time commitment
- The study lasts about one year and includes regular visits and tests.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 75
You may be able to join if
- Current or former smokers with a smoking history of greater than or equal to (≥) 10 pack-years
- Moderate-to-severe COPD (post-Bronchodilator (BD) Forced Expiratory Volume in 1 Second (FEV₁)/forced vital capacity (FVC) less than (\<) 70 percent...
- Modified Medical Research Council Dyspnea Scale (mMRC-DS) grade ≥2
- Exacerbation history of ≥2 moderate or ≥1 severe exacerbations within the year prior to inclusion.
- Background double therapy [long-acting β₂-agonists (LABA) + long-acting muscarinic antagonists (LAMA)] or triple therapy [inhaled corticosteroids...
You likely can't join if
- Have a known pre-existing, clinically important lung condition other than COPD.
- Have a current or recent acute, active infection before screening and up to randomization.
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Newport Beach, California, United States
- San Diego, California, United States
- Denver, Colorado, United States
- Miami, Florida, United States
- Miami Lakes, Florida, United States
- Orlando, Florida, United States
- Westchester, Illinois, United States
- Indianapolis, Indiana, United States
- Muncie, Indiana, United States
- Southfield, Michigan, United States
- Maplewood, Minnesota, United States
- DuBois, Pennsylvania, United States
- Denison, Texas, United States
- Lewisville, Texas, United States
- Kirkland, Washington, United States
- Buenos Aires, Argentina
- Mendoza, Argentina
- Río Cuarto, Argentina
- Santa Rosa, Argentina
+ 45 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Newport Beach, California, United States; San Diego, California, United States; Denver, Colorado, United States; Miami, Florida, United States; Miami Lakes, Florida, United States and 59 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.