Clinical trial for Complex Regional Pain Syndrome (CRPS)
Official title Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients
ClinicalTrials.gov ID: NCT07791966
What this study is testing
- What it's testing
- The study wants to see whether transcranial alternating current stimulation (tACS) changes pain‑avoidance behavior and related brain signals in chronic pain patients.
- Who it's for
- Adults who have Complex Regional Pain Syndrome (CRPS) and can safely undergo brain imaging.
- What's involved
- Participants will receive either real or fake tACS while completing questionnaires, a pain‑avoidance task, and resting periods. During these times, brain activity will be recorded with MEG and EEG, and skin and heart responses will be measured. An MRI scan will be done if no incompatible implants are present.
- Time commitment
- The study lasts about a day of visits, including questionnaires, stimulation sessions, and brain‑imaging recordings.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 years or older
- Diagnosed with Complex Regional Pain Syndrome (CRPS) Type I or II, based on Budapest criteria
- 6 months or more of medically refractory severe pain
- Average daily pain for past 30 days \>= 5 on 0-10 scale
- Presence of allodynia and/or hyperalgesia
You likely can't join if
- Age under 18 years, pregnant women of any age
- Any co-occurring pain diagnosis that might confound with allodynia/hyperalgesia resulting from CRPS reflecting a malfunction in sensory processing...
- Less than six months of medically refractory pain
- Average daily pain for past 30 days \<5 on 0-10 scale
- Absence of allodynia and/or hyperalgesia
- Concurrent neurostimulation therapies such as SCS
See the full eligibility criteria
- Age 18 years or older
- Diagnosed with Complex Regional Pain Syndrome (CRPS) Type I or II, based on Budapest criteria
- 6 months or more of medically refractory severe pain
- Average daily pain for past 30 days \>= 5 on 0-10 scale
- Presence of allodynia and/or hyperalgesia
- Lower extremity CRPS: bilateral or unilateral pain
- Not concurrently treated with neurostimulation therapies such as spinal cord stimulators (SCS)
- Absence of co-occurring severe psychiatric disorders (PHQ-9\<19 and/or GAD-7\<14)
- Age under 18 years, pregnant women of any age
- Any co-occurring pain diagnosis that might confound with allodynia/hyperalgesia resulting from CRPS reflecting a malfunction in sensory processing within the CNS.
- Less than six months of medically refractory pain
- Average daily pain for past 30 days \<5 on 0-10 scale
- Absence of allodynia and/or hyperalgesia
- Concurrent neurostimulation therapies such as SCS
- Severe disorders or conditions (e.g., cardiovascular, liver issues), terminal illness
- PHQ-9\>19 and/or GAD-7\>14 (severe depression/anxiety)
The study team makes the final eligibility decision.
Where it is enrolling
- Cleveland, Ohio, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Cleveland, Ohio, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.