Infertility study: CAPA-IVM System
Official title Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer
ClinicalTrials.gov ID: NCT07801105
What this study is testing
- What it's testing
- This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. It also looks at how safe the process is and how well the eggs grow into healthy embryos.
- Who it's for
- You may be able to join if you have infertility and are willing to have up to three egg retrievals.
- What's involved
- You will have up to three egg retrieval procedures. The eggs will be matured in the lab, fertilized, and grown into embryos. The embryos will be checked for normal chromosomes, and one healthy embryo may be frozen or transferred to your uterus.
- Time commitment
- The study lasts until you have had up to three retrievals, with follow‑up visits to monitor safety and pregnancy outcomes.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, women only
You may be able to join if
- Signed informed consent.
- Female participant aged 18-35 years.
- Diagnosis of infertility requiring IVF/ICSI, including unexplained infertility or mild male factor infertility.
- BMI 18-30 kg/m².
- AMH ≥2.5 ng/mL.
You likely can't join if
- Prior ovarian surgery.
- Ovarian endometrioma.
- Inaccessible ovaries.
- Significant uterine factor expected to compromise implantation, pregnancy, or live birth.
- Significant medical comorbidity that would increase risk of TVOR, pregnancy, or study participation.
- AMH \<2.5 ng/mL.
See the full eligibility criteria
- Signed informed consent.
- Female participant aged 18-35 years.
- Diagnosis of infertility requiring IVF/ICSI, including unexplained infertility or mild male factor infertility.
- BMI 18-30 kg/m².
- AMH ≥2.5 ng/mL.
- AFC ≥12.
- Basal FSH \<8 IU/L.
- Ovaries accessible for transvaginal retrieval.
- Willing to undergo serial unstimulated TVORs with adaptive retrieval timing.
- Willing to undergo CAPA-IVM, ICSI, blastocyst culture, PGT-A, embryo vitrification/accumulation, and single euploid embryo transfer.
- Willing to undergo serial ultrasound and endocrine monitoring.
- Willing and able to comply with study procedures and follow-up.
- Prior ovarian surgery.
- Ovarian endometrioma.
- Inaccessible ovaries.
- Significant uterine factor expected to compromise implantation, pregnancy, or live birth.
- Significant medical comorbidity that would increase risk of TVOR, pregnancy, or study participation.
- AMH \<2.5 ng/mL.
- AFC \<12.
- Basal FSH ≥8 IU/L.
- BMI \ 30 kg/m².
- Current smoking or nicotine use within 3 months of screening.
- Active pelvic infection, untreated STI, or acute urinary tract infection.
- Contraindication to transvaginal oocyte retrieval, anesthesia/sedation, pregnancy, or antibiotic prophylaxis.
- Known chromosomal abnormality in the participant or sperm source that would confound study outcome assessment.
- Severe male factor infertility requiring surgical sperm retrieval, unless specifically permitted by the final protocol.
- Recent exposure to teratogenic radiation, drugs, or toxins.
- Current participation in another treatment clinical trial that may confound outcomes.
- Previous participation in the CARE study.
The study team makes the final eligibility decision.
Where it is enrolling
- Bedford, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 35 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Bedford, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.