Post-exercise Period study: Resistance Exercise
Official title Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males.
ClinicalTrials.gov ID: NCT07884539
What this study is testing
- What it's testing
- The study will see whether adding a ketone monoester to protein after resistance exercise changes how the body processes the amino acid phenylalanine and overall protein metabolism.
- Who it's for
- Young, trained men who regularly do resistance exercise.
- What's involved
- Participants will drink either a ketone monoester with protein or protein alone after a workout, then have blood samples taken to measure amino acids, insulin, glucose, ketone levels, and protein breakdown.
- Time commitment
- The study lasts a few days, with a single exercise session and several blood draws after the workout.
You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, men only. Healthy volunteers may be eligible.
You may be able to join if
- Adult male aged 18-35 at time of initial screening.
- Generally healthy (no uncontrolled diseases or conditions) as determined by health history, and if necessary, physician clearance.
- BMI between 18.5 and 30 kg m-2 (inclusive) at time of initial screening.
- Maintenance of a stable body weight for at least 3 months prior to participation and willingness to maintain this weight during the duration of this...
- Maintained stable use of medication and supplements (which are not limited by the
You likely can't join if
- ), and stable dietary and lifestyle habits for the last 3 months prior to screening and agree to maintain them throughout the study
- Minimum 6 months of resistance training experience with a minimum of 2 sessions/week
- Presence of cardiovascular, metabolic, renal, hepatic, neuromuscular, or gastrointestinal disease that could interfere with study participation or...
- History of severe cardiovascular events (myocardial infarction, stroke, severe hypertension)
- Any musculoskeletal injury that would prevent completion of the resistance exercise protocol
- Ketone supplementation or adherence to a ketogenic diet
See the full eligibility criteria
- Adult male aged 18-35 at time of initial screening.
- Generally healthy (no uncontrolled diseases or conditions) as determined by health history, and if necessary, physician clearance.
- BMI between 18.5 and 30 kg m-2 (inclusive) at time of initial screening.
- Maintenance of a stable body weight for at least 3 months prior to participation and willingness to maintain this weight during the duration of this study
- Maintained stable use of medication and supplements (which are not limited by the
- ), and stable dietary and lifestyle habits for the last 3 months prior to screening and agree to maintain them throughout the study
- Minimum 6 months of resistance training experience with a minimum of 2 sessions/week
- Presence of cardiovascular, metabolic, renal, hepatic, neuromuscular, or gastrointestinal disease that could interfere with study participation or data interpretation or make the resistance training unsafe
- History of severe cardiovascular events (myocardial infarction, stroke, severe hypertension)
- Any musculoskeletal injury that would prevent completion of the resistance exercise protocol
- Ketone supplementation or adherence to a ketogenic diet
- Use of medication known to influence protein metabolism
- Participation in a stable-isotope tracer study in the past 6 months
- Tobacco/nicotine use
- Undergoing exercise sessions more than 5 days/week.
- Metal implants
- Paralysis, limb loss, or congenital or acquired absence of skeletal muscle
- Individuals with Phenylketonuria (PKU)
- Dairy allergy or lactose intolerance
The study team makes the final eligibility decision.
Where it is enrolling
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Montreal, Quebec, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.