Clinical trial for Depression - Major Depressive Disorder
Official title Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease
ClinicalTrials.gov ID: NCT07896343
What this study is testing
- What it's testing
- This study is looking at how a part of the brain called the orbitofrontal cortex decides on rewards versus risks in people with depression.
- Who it's for
- You may be able to join if you are an adult in the hospital, have depression, and already have brain electrodes placed for medical reasons.
- What's involved
- You will play a short computer game about 20 minutes long while your brain activity is recorded from the existing electrodes. You will also rate your mood before each game.
- Time commitment
- The study lasts during your hospital stay and includes a few 20‑minute game sessions.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- 18 years of age or older
- Implanted with stereo-EEG (sEEG) depth electrodes, including at least one electrode in the orbitofrontal cortex (OFC)
- Enrolled in the PRESIDIO trial (NCT04004169) of deep brain stimulation for treatment-resistant depression and undergoing inpatient sEEG monitoring as...
- Undergoing inpatient sEEG monitoring for a clinical indication other than depression (e.g., seizure localization in refractory epilepsy)
- No current diagnosis of major depressive disorder, confirmed by clinical psychiatric evaluation (e.g., MINI and symptom scales)
You likely can't join if
- Current or past DSM-5 diagnosis of a psychotic disorder or major depressive disorder with psychotic features
- Current or past DSM-5 diagnosis of bipolar or related disorder
- Current obsessive-compulsive disorder
- Intellectual disability
- Autism spectrum disorder
- Borderline, antisocial, histrionic, or narcissistic personality disorder
See the full eligibility criteria
- 18 years of age or older
- Implanted with stereo-EEG (sEEG) depth electrodes, including at least one electrode in the orbitofrontal cortex (OFC)
- Enrolled in the PRESIDIO trial (NCT04004169) of deep brain stimulation for treatment-resistant depression and undergoing inpatient sEEG monitoring as part of that trial
- Undergoing inpatient sEEG monitoring for a clinical indication other than depression (e.g., seizure localization in refractory epilepsy)
- No current diagnosis of major depressive disorder, confirmed by clinical psychiatric evaluation (e.g., MINI and symptom scales)
- Current or past DSM-5 diagnosis of a psychotic disorder or major depressive disorder with psychotic features
- Current or past DSM-5 diagnosis of bipolar or related disorder
- Current obsessive-compulsive disorder
- Intellectual disability
- Autism spectrum disorder
- Borderline, antisocial, histrionic, or narcissistic personality disorder
- Impaired decision-making capacity or cognitive deficits that preclude informed consent or task completion
- Employee of the investigator or study site with direct involvement in the study, or family member of the investigator Control (non-depressed) cohort only: \ Epileptiform abnormalities involving the OFC, OFC dysplasia...
The study team makes the final eligibility decision.
Where it is enrolling
- San Francisco, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at San Francisco, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.